The membrane skeleton is four structural proteins that include & spectrin, ankyrin, protein 4.1 & actin
Spectrin is major protein of the cytoskeleton & its two chains ( & ) are aligned in an antiparallel manner . & chains are loosely interconnected forming a dimer, one dimer interact with another, forming a head to head tetramer.
Ankyrin binds spectrin & in turn binds tightly to band 3 securing attachment of spectrin to membrane.
band 3 is anion exchange protein permits exchanges of Cl- for HCO3+.
Actin binds to the tail of spectrin & to protein 4.1 which in turn binds to integral proteins, glycophorins A, B & C.
Glycophorins A,B,C are transmembrane glycoproteins